{"product_id":"antiestrogens-induce-immunosuppression-paperback","title":"Antiestrogens Induce Immunosuppression - Paperback","description":"\u003cdiv\u003e\u003cp style=\"text-align: right;\"\u003e\u003ca href=\"https:\/\/reportcopyrightinfringement.com\/\" target=\"_blank\" rel=\"nofollow\"\u003e\u003cb\u003eReport copyright infringement\u003c\/b\u003e\u003c\/a\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cp\u003eby \u003cb\u003eChristian Joffroy\u003c\/b\u003e (Author)\u003c\/p\u003e\u003cp\u003eAntiestrogens (AE) like tamoxifen belong to the most commonly used drugs in the therapy of estrogen receptor positive breast cancer. Nevertheless, relapses frequently occur during treatment indicating development of drug resistance. Concerning the underlying mechanisms, the finding of AE induced TGF  in breast cancer cells appears to be relevant both with respect to TGF 's cell autonomous function as a mediator of cancer progression and its function as an immune regulator. To investigate the potential role of tumor derived, AE induced TGF  as a suppressor of the host's immune response, heterologous and autologous in vitro assays have been established in this work. Application of AE led to an impaired antitumor immune response, which could be restored by a neutralizing TGF  antibody. The work at hand thus provides evidence for an AE treatment induced, TGF  driven immunosuppression in the tumor microenvironment, a mechanism that could critically contribute to development of AE resistance during therapy.\u003c\/p\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 116\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.28 x 9 x 6 IN\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e June 26, 2010\u003c\/div\u003e\n            ","brand":"BooksCloud","offers":[{"title":"Default Title","offer_id":48080104194307,"sku":"9783838116716","price":82.22,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0588\/9310\/7359\/files\/A2HjfNeGFg9783838116716.webp?v=1778194408","url":"https:\/\/annizon.com\/en-gb\/products\/antiestrogens-induce-immunosuppression-paperback","provider":"annizon.com","version":"1.0","type":"link"}